Demystifying Death: Reflections on End-of-Life Doula Work.

End-of-life doulas (EOLDs) represent a portion of a broader mobilization of end-of-life care practitioners to normalize discussions of death and assist dying persons and their caregivers in navigating the dying process. EOLDs primarily focus on creating a supportive environment for the dying and their loved ones. Research on the burgeoning care profession has documented the backgrounds and services of EOLD work; however, literature has overlooked EOLDs' personal reflections on their work.

Identifying Biomarkers of Spinal Muscular Atrophy for Further Development.

Background: Spinal muscular atrophy (SMA) is caused by bi-allelic, recessive mutations of the survival motor neuron 1 (SMN1) gene and reduced expression levels of the survival motor neuron (SMN) protein. Degeneration of alpha motor neurons in the spinal cord causes progressive skeletal muscle weakness. The wide range of disease severities, variable rates of decline, and heterogenous clinical responses to approved disease-modifying treatment remain poorly understood and limit the ability to optimize treatment for patients.

The RNA-Binding Protein HuR Posttranscriptionally Regulates IL-2 Homeostasis and CD4 Th2 Differentiation.

Posttranscriptional gene regulation by RNA-binding proteins, such as HuR (), fine-tune gene expression in T cells, leading to powerful effects on immune responses. HuR can stabilize target mRNAs and/or promote translation by interacting with their 3' untranslated region adenylate and uridylate-rich elements. It was previously demonstrated that HuR facilitates Th2 cytokine expression by mRNA stabilization.