Publications by authors named "J Given"
Background: The British horseracing industry is committed to reducing equine fatalities in jump racing. Race-related fatalities are a major welfare concern and threaten the sport's social licence to operate.
Objectives: To describe the risk of, and determine risk factors for, fatality in British jump racing.
Article Synopsis
- - The study investigated the impact of prolonged extreme heat exposure during early pregnancy (specifically during the August 2003 heatwave in France) on the risk of neural tube defects (NTDs) in newborns.
- - Researchers analyzed data from the Paris Registry of Congenital Malformations, finding that out of 1272 NTD cases recorded between 1994 and 2018, ten cases were linked to conceptions during the extreme heat period, showing a significantly higher risk (relative risk = 2.14).
- - Overall, the findings indicate that exposure to extreme heat in the early stages of pregnancy is associated with an increased risk of NTDs, highlighting potential environmental health risks during critical periods of fetal development.
Heterosis occurs in individuals when genetic diversity, e.g., heterozygosity, increases fitness.
View Article and Find Full Text PDFBackground: Hirschsprung's disease is a rare congenital anomaly of the colon with absence of the ganglionic nerve cells. The treatment of the anomaly is surgical.
Methods: This population-based data-linkage cohort study was part of the EUROlinkCAT project and investigated mortality and morbidity for the first 5 years of life for European children diagnosed with Hirschsprung's disease.
Objectives: To compare 5-year survival rate and morbidity in children with spina bifida, transposition of great arteries (TGA), congenital diaphragmatic hernia (CDH) or gastroschisis diagnosed prenatally with those diagnosed postnatally.
Methods: Population-based registers' data were linked to hospital and mortality databases.
Results: Children whose anomaly was diagnosed prenatally (n = 1088) had a lower mean gestational age than those diagnosed postnatally (n = 1698) ranging from 8 days for CDH to 4 days for TGA.