Publications by authors named "J Gilchrist"
Background: To compare the effectiveness of four surveillance strategies for detecting SARS-CoV-2 within the homeless shelter population in Hamilton, ON and assess participant adherence over time for each surveillance method.
Methods: This was an open-label, cluster-randomized controlled trial conducted in eleven homeless shelters in Hamilton, Ontario, from April 2020 to January 2021. All participants who consented to the study and participated in the surveillance were eligible for testing by self-swabbing.
Background: PET imaging of activated microglia has improved our understanding of the pathology behind disability progression in MS, and pro-inflammatory microglia at 'smoldering' lesion rims have been implicated as drivers of disability progression. The P2X R is upregulated in the cellular membranes of activated microglia. A single-tissue dual-input model was applied to quantify P2X R binding in the normal appearing white matter, perilesional areas and thalamus among progressive MS patients, healthy controls and newly diagnosed relapsing MS patients.
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- The study investigates the relationship between IL-6 signaling, particularly through the SNP rs2228145, and the risk of developing tuberculosis (TB), considering that inhibitors of IL-6 signaling might increase TB progression risk.
- The researchers conducted a meta-analysis of various genome-wide association studies (GWAS) to analyze genetic data and extract effect estimates related to the C allele of rs2228145, which is associated with reduced IL-6 signaling.
- Preliminary findings include data from 17 GWAS, covering a substantial sample of individuals with tuberculosis and a large control population, aiming to understand how genetic factors might influence TB susceptibility.
Introduction: The present study examined the between- and within-person associations among negative weight-related experiences, weight bias internalization, and body shame, embarrassment, and pride in adolescents.
Methods: Participants were 93 Canadian students (M = 15.54, 59.
The mechanisms by which respiratory viruses predispose to secondary bacterial infections remain poorly characterized. Using 2,409 nasopharyngeal swabs from 300 infants in Botswana, we performed a detailed analysis of factors that influence the dynamics of bacterial pathobiont colonization during infancy. We quantify the extent to which viruses increase the acquisition of , , and .
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