Publications by authors named "J Gil-Serrano"
Article Synopsis
- Hereditary angioedema (HAE) is a rare disorder that causes localized swelling due to an increase in bradykinin, but the impact of inflammation during attacks hasn't been well-studied.
- Researchers analyzed blood samples from 78 HAE patients during both symptom-free periods and active attack phases, measuring inflammatory markers like serum amyloid A (SAA), erythrocyte sedimentation rate (ESR), and D-Dimer.
- Findings showed that during attacks, 88% of patients had elevated SAA, 65% had increased ESR, and 71% showed higher D-Dimer levels, suggesting a significant inflammatory response during HAE attacks compared to baseline levels.
A Core Outcome Set for Efficacy of Acute Treatment of Hereditary Angioedema.
J Allergy Clin Immunol Pract
June 2024
Background: Clinical trials investigating drugs for the acute treatment of hereditary angioedema attacks have assessed many different outcomes. This heterogeneity limits the comparability of trial results and may lead to selective outcome reporting bias and a high burden on trial participants.
Objective: To achieve consensus on a core outcome set composed of key outcomes that ideally should be used in all clinical efficacy trials involving the acute treatment of hereditary angioedema attacks.
Purpose Of Review: The purpose of this review is to provide a better understanding of anaphylaxis pathophysiology and describe the underlying mechanisms, effector cells, and the potential biomarkers involved depending on the anaphylaxis endotypes.
Recent Findings: New insight into the potential relevance of pathways others than IgE-dependent anaphylaxis has been unraveled, as well as other biomarkers than tryptase, such as the role of platelet activation factor, basogranulin, dipeptidyl peptidase I, CCL-2, and other cytokines.
Summary: Gaining knowledge of all the mediators and cellular activation/communication pathways involved in each endotype of anaphylaxis will allow the application of precision medicine in patients with anaphylactic reactions, providing insights to the most appropriate approach in each case and helping to stratify severity and risk prediction.
Anaphylactic shock to meropenem with ertapenem tolerance: A case report.
J Allergy Clin Immunol Pract
September 2020