Publications by authors named "J Giezen"
Article Synopsis
- - The study investigates the relationship between blood clot characteristics, such as composition and mechanical properties, and their visibility on CT imaging to improve endovascular thrombectomy outcomes.
- - Five different red blood cell (RBC) volume suspensions created two distinct clot types: fibrin-rich (0% RBCs) and RBC-rich (>90% RBCs), revealing significant differences in density, stiffness, and contraction between them.
- - Findings suggest that CT imaging can effectively indicate the RBC content of clots and may help predict their behavior, but further research is needed on clots with intermediate RBC and platelet levels.
Thrombus composition and mechanical properties significantly impact the ease and outcomes of thrombectomy procedures in patients with acute ischemic stroke. A wide variation exists in the composition of thrombi between patients. If a relationship can be determined between the composition of a thrombus and its mechanical behaviour, as well as between the composition of a thrombus and its radiological imaging characteristics, then there is the potential to personalise thrombectomy treatment based on each individual thrombus.
View Article and Find Full Text PDFThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing to disrupt personal lives, global healthcare systems, and economies. Hence, there is an urgent need for a vaccine that prevents viral infection, transmission, and disease. Here, we present a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2 spike protein.
View Article and Find Full Text PDFBackground and Purpose- Coagulation factor XI (FXI) is a novel target for antithrombotic therapy addressed by various therapeutic modalities currently in clinical development. The expected magnitude of thrombotic event reduction mediated by targeting FXI is unclear. Methods- We analyzed the association of 2 common genetic variants, which alter levels of FXI, with a range of human phenotypes.
View Article and Find Full Text PDFIn patients with acute coronary syndrome, dual antiplatelet therapy with aspirin and a P2Y12 inhibitor like prasugrel is prescribed for one year. Here, we investigated how the hemostatic function of platelets recovers after discontinuation of prasugrel treatment. Therefore, 16 patients who suffered from ST-elevation myocardial infarction were investigated.
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