Effect of physical activity on the pharmacokinetics of ceftazidime in mice.

Background: The aim of the present work was to assess comparatively the pharmacokinetic profile of ceftazidime (CAZ) in trained and non-trained mice.

Methods: The study was performed on 256 mice divided at random into four groups: long-term physically trained mice with (E1a) and without (E1b) physical activity prior to the administration of CAZ, and untrained mice with (E2a) and without (E2b) physical activity prior to the administration of the antibiotic. CAZ was administered intramuscularly (25 mg/kg) to all mice, and blood samples were obtained at different time points.

End-tidal CO2 pressure determinants during hemorrhagic shock.

Objectives: To examine the relationship between end-tidal CO2 (PETCO2) and its physiological determinants, pulmonary blood flow (cardiac output, CO) and CO2 production (VCO2), in a model of hemorrhagic shock during fixed minute ventilation.

Design And Setting: Prospective, observational study in a research laboratory at a university center.

Subjects And Interventions: Six anesthetized, intubated, and mechanically ventilated mongrel dogs.