Publications by authors named "J Gerald Quirk"
Cancer remains a leading cause of mortality, with aggressive, treatment-resistant tumors posing significant challenges. Current combination therapies and imaging approaches often fail due to disparate pharmacokinetics and difficulties correlating drug delivery with therapeutic response. In this study, we developed radionuclide-activatable theranostic nanoparticles (NPs) comprising folate receptor-targeted bimetallic organo-nanoparticles (Gd-Ti-FA-TA NPs).
View Article and Find Full Text PDFAntiperovskites are generating considerable interest as potential solid electrolyte materials for solid-state batteries because of their promising ionic conductivity, wide electrochemical windows, stability, chemical diversity and tunability, and low cost. Despite this, there is a surprising lack of a systematic study of antiperovskite surfaces and their influence on the performance of these materials in energy storage applications. This is rectified here by providing a comprehensive density functional theory investigation of the surfaces of MOX (M = Li or Na; X = Cl or Br) antiperovskites.
View Article and Find Full Text PDFObjectives: The aim of this study was to systematically review the literature to assess the application of AI-based interventions in lung cancer screening, and its future implications.
Methods: Relevant published literature was screened using PRISMA guidelines across three databases: PubMed, Scopus, and Web of Science. Search terms for article selection included "artificial intelligence," "radiology," "lung cancer," "screening," and "diagnostic.
Article Synopsis
- Researchers are developing better animal models for aneurysmal subarachnoid hemorrhage (SAH) to study the condition more effectively, as current models fail to mimic the long-term cognitive issues experienced by patients.
- A new mouse model has been created that reliably produces significant long-term cognitive deficits by modifying a previous injection method, allowing for consistent results.
- This mouse model effectively mirrors key characteristics of SAH in humans, making it a valuable tool for exploring SAH-related brain injury and potential treatments for cognitive impairments.
Article Synopsis
- Scientists made a cool new material called a calcium-based electride that works at room temperature.
- This material has special electrons that don't move around much, which means it doesn't conduct electricity very well.
- They found that this new material can react with other chemicals to create new compounds, showing how it can be used in different ways.