Publications by authors named "J Gerald Kenna"
In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals.
Toxicol Appl Pharmacol
November 2024
Article Synopsis
- An adapted in vitro pharmacology profiling panel (APPP) was created to evaluate the effects of 129 cosmetic chemicals, including both traditional pharmaceutical targets and additional targets related to systemic toxicities.
- The study demonstrated strong internal data consistency, with reproducible results across different testing concentrations and compatibility with existing ToxCast and drug excipient data.
- The findings highlight how this panel can aid in risk assessments for cosmetic chemicals without the need for new animal testing, supported by case studies and discussions of new methodologies.
Objective: Previous studies have revealed a substantial between-centre variability in DCE-MRI biomarkers of hepatocellular function in rats. This study aims to identify the main sources of variability by comparing data measured at different centres and field strengths, at different days in the same subjects, and over the course of several months in the same centre.
Materials And Methods: 13 substudies were conducted across three facilities on two 4.
Airway pressure release ventilation (APRV) is a protective mechanical ventilation mode for patients with acute respiratory distress syndrome (ARDS) that theoretically may reduce ventilator-induced lung injury (VILI) and ARDS-related mortality. However, there is no standard method to set and adjust the APRV mode shown to be optimal. Therefore, we performed a meta-regression analysis to evaluate how the four individual APRV settings impacted the outcome in these patients.
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