Publications by authors named "J Gera"

Domain-specific vocabulary, which is crucial in fields such as Information Retrieval and Natural Language Processing, requires continuous updates to remain effective. Incremental Learning, unlike conventional methods, updates existing knowledge without retraining from scratch. This paper presents an incremental learning algorithm for updating domain-specific vocabularies.

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Hormones mediate inter-organ signaling which is crucial in orchestrating diverse behaviors and physiological processes including sleep and activity, feeding, growth, metabolism and reproduction. The pars intercerebralis and pars lateralis in insects represent major hubs which contain neurosecretory cells (NSC) that produce various hormones. To obtain insight into how hormonal signaling is regulated, we have characterized the synaptic connectome of NSC in the adult brain.

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Article Synopsis
  • - High-caloric diets can disrupt the extracellular matrix (ECM) in organs, particularly the heart, leading to health issues, though the exact mechanisms are not well understood.
  • - Research using Drosophila shows that high sugar intake activates JNK signaling, resulting in increased fatty acid oxidation (FAO) in specific cells, which then upregulates the cytokine Unpaired 3 (Upd3).
  • - The release of Upd3 prompts the expression of the ECM protein Pericardin, causing cardiac fibrosis, highlighting a novel connection between FAO and ECM remodeling that could have implications for diabetic complications.
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Animals have evolved a multitude of signaling pathways that enable them to orchestrate diverse physiological processes to tightly regulate systemic homeostasis. This signaling is mediated by various families of peptide hormones and cytokines that are conserved across the animal kingdom. In this review, we primarily focus on the unpaired (Upd) family of proteins in Drosophila which are evolutionarily related to mammalian leptin and the cytokine interleukin 6.

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