Piperine's potential in treating polycystic ovarian syndrome explored through in-silico docking.

Polycystic Ovarian Syndrome (PCOS) is a multifaceted metabolic and hormonal condition that impacts women in their procreative ages, identified by ovarian dysfunction, hyperandrogenaemia overweight and insulin insensitivity. The piperine, an important alkaloid compound of black pepper has shown promise in modulating various physiological processes. In this work, employed computational docking studies to explore the potential of piperine as a treatment for PCOS.

An Exercise Immune Fitness Test to Unravel Disease Mechanisms-A Proof-of-Concept Heart Failure Study.

: Cardiorespiratory fitness positively correlates with longevity and immune health. Regular exercise may provide health benefits by reducing systemic inflammation. In chronic disease conditions, such as chronic heart failure and chronic fatigue syndrome, mechanistic links have been postulated between inflammation, muscle weakness, frailty, catabolic/anabolic imbalance, and aberrant chronic activation of immunity with monocyte upregulation.

Removal of dermal piercings.

We report a case of a patient with dermal piercings of the hand that were used to anchor body jewelry. The piercings had become infected and were causing the patient pain. She requested that they be removed in the emergency department (ED).

A Review of Commonly used Health-Related Quality of Life instruments in Gynecological Cancer Survivors.

The number of cancer survivors is increasing steadily due to an aging population, continuing improvement in early detection, and treatment. Comparative effectiveness studies and clinical trials are being done to assess late effects of treatment and health-related quality of life. This is in addition to long-term follow-up to assess survival.

A Case of Successful Management of Peripartum Cardiomyopathy.

Peripartum Cardiomyopathy is a rare type of cardiomyopathy that occurs during late pregnancy or in early postpartum period and is a life threatening condition. It presents with heart failure secondary to left ventricular systolic dysfunction. Here the LVEF is < 45%, with/without LV dilatation.