Publications by authors named "J Geoghegan"
Over the last decade metagenomic sequencing has facilitated an increasing number of virome-scale studies, leading to an exponential expansion in understanding of virus diversity. This is partially driven by the decreasing costs of metagenomic sequencing, improvements in computational tools for revealing novel viruses, and an increased understanding of the key role that viruses play in human and animal health. A central concern associated with this remarkable increase in the number of virome-scale studies is the lack of broadly accepted "gold standards" for reporting the data and results generated.
View Article and Find Full Text PDFHuman respiratory syncytial virus (RSV) is a major cause of acute respiratory infection. In 2020, RSV was eliminated from New Zealand due to non-pharmaceutical interventions (NPI) used to control the spread of SARS-CoV-2. However, in 2021, following a brief quarantine-free travel agreement with Australia, there was a large-scale nationwide outbreak of RSV that led to reported cases more than five-times higher than typical seasonal patterns.
View Article and Find Full Text PDFSupporting Regional Upper Limb Arthroplasty: The Impact of Establishing an Upper Limb Orthopaedic Network.
J Shoulder Elb Arthroplast
October 2024
Background And Objectives: The management of complex upper limb arthroplasty has received national guidelines supporting the use of a regional network. An upper limb network was established for both elbow and shoulder arthroplasty. This study evaluates the impact of establishing this network over a 5-year period.
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- Researchers isolated various monoclonal antibodies (mAbs) from human B cells that target the hemagglutinin (HA) protein of influenza, focusing on both H1 and H3 subtypes.
- The study improved the effectiveness of H1 mAbs against contemporary strains and identified potential viral escape routes using deep mutational scanning.
- For H3 mAbs, advanced imaging techniques mapped specific epitopes, showing how these antibodies might guide the development of next-generation vaccines that can provide broader protection against influenza.
Article Synopsis
- Acetic acid shows potential as an alternative to antibiotics for treating burn wounds, but its effectiveness is limited by its poor material properties for retention and site specificity.
- In this study, acetic acid was used as both a gelling agent and an antimicrobial component in alginate fluid gels, with the microstructure depending on the concentration of acetic acid.
- The resulting fluid gels exhibited improved sprayability and long-lasting surface retention, while maintaining antimicrobial effectiveness against common pathogens.