Publications by authors named "J Geddes"
Background: Links between personality disorders and antisocial outcomes has not examined individual personality disorders, and the contribution of comorbidities remain uncertain. Previous systematic reviews are dated.
Aims: To synthesise evidence from observational studies on the risk of antisocial outcomes and recidivism associated with personality disorders.
Objective: To assess whether the antiseizure medication levetiracetam may improve cognition in individuals with Alzheimer's disease who have not previously experienced a seizure.
Methods: We performed a randomized, double-blind, placebo-controlled crossover pilot study in individuals with mild-to-moderate Alzheimer's disease. Electroencephalography was performed at baseline and those with active epileptiform discharges were excluded.
Article Synopsis
- Understanding the complexities of cardiovascular control through the autonomic system is challenging, as shown by the ongoing debates around conditions like orthostatic intolerance.
- This study created a mathematical model to simulate the sympathetic control of the cardiovascular system, testing young women with varying responses to a head-up-tilt test and measuring their heart rate and blood pressure.
- The model successfully predicted blood pressure and flow dynamics, identifying seven key parameters that could serve as biomarkers for patient classification, highlighting the potential of computational methods in studying autonomic system pathologies.
Background: In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during acute COVID-19 would be associated with improved health-related quality of life (HRQoL) 1 year after discharge.
Methods: Adults admitted to hospital between February 2020 and March 2021 for COVID-19 and meeting current guideline recommendations for dexamethasone treatment were included using two prospective UK cohort studies (Post-hospitalisation COVID-19 and the International Severe Acute Respiratory and emerging Infection Consortium).