Publications by authors named "J Gaynor"
Neonates with congenital heart disease (CHD) who undergo cardiopulmonary bypass (CPB) are at high-risk for unfavorable neurodevelopmental (ND) outcomes and are recommended for ND evaluation (NDE); however, poor rates have been reported. We aimed to identify risk factors associated with lack of NDE. This single-center retrospective observational study included neonates < 30 days old who underwent CPB and survived to discharge between 2012 and 2018.
View Article and Find Full Text PDFBackground: Individuals have a higher risk of cardiovascular disease later in life if they give birth to a child with congenital heart disease (CHD). The mechanism of this association has not been well documented.
Objectives: The authors aimed to describe the prevalence of cardiovascular disease and risk factors in women and birthing individuals 18 to 23 years after delivery of a child with CHD compared to normative data.
This paper uses the concept of resilience engineering as an organizing principle to discuss best practices that evolved within health science/medical libraries in the United States during COVID-19 crisis, focusing on the period March - August 2020. Protection of library staff, assistance to medical staff, reducing the circulation of misinformation and public health consumerism all required substantial changes to standard processes. These process changes had to arise in the context of both physical isolation and information overload.
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- * In this study, preterm fetal lambs were subjected to reduced oxygen levels using the EXTEND model, resulting in noticeable growth restrictions and changes in lung structure compared to those with normal oxygen levels.
- * Key findings included fewer blood vessels, increased muscularization in peripheral vessels, enlarged airspaces, and a drop in specific lung cell types and proteins crucial for lung function, indicating that fetal hypoxia mainly affects airway and surfactant production development.
Fetal brain size is decreased in some children with complex CHDs, and the distribution of blood and accompanying oxygen and nutrients is regionally skewed from early fetal life dependent on the CHD. In transposition of the great arteries, deoxygenated blood preferentially runs to the brain, whereas the more oxygenated blood is directed towards the lungs and the abdomen. Knowledge of whether this impacts intrauterine organ development is limited.
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