Publications by authors named "J Garrity"
Significance: Women are at increased risk for mood disorders, which may be partly attributed to exposure to endocrine-disrupting chemicals (EDCs) during sensitive periods such as pregnancy. Exposure during these times can impact brain development in the offspring, potentially leading to mood disorders in later life. Additionally, fluctuating levels of endogenous estrogens, as seen during pregnancy, or the use of oral contraceptives, can further elevate this risk.
View Article and Find Full Text PDFArticle Synopsis
- Granulomatosis with polyangiitis (GPA) is a rare autoimmune disease that can lead to optic neuropathy, caused by factors like compressive, inflammatory, or ischemic conditions.
- A study reviewed 12 patients with GPA-associated optic neuropathy, analyzing initial and final visual acuities to determine potential outcomes based on the cause of neuropathy.
- Results showed variable visual outcomes, particularly that compressive optic neuropathy improved in some cases, while ischemic optic neuropathy generally remained stable or worsened over time.
Opioid-induced respiratory depression (OIRD) deaths are ~80,000 a year in the US and are a major public health issue. Approximately 90% of fatal opioid-related deaths are due to synthetic opioids such as fentanyl, most of which is illicitly manufactured and distributed either on its own or as an adulterant to other drugs of abuse such as cocaine or methamphetamine. Other potent opioids such as nitazenes are also increasingly present in the illicit drug supply, and xylazine, a veterinary tranquilizer, is a prevalent additive to opioids and other drugs of abuse.
View Article and Find Full Text PDFPurpose: The purpose of this study was to describe the clinical features, management, outcomes, and diagnostic pitfalls in a large series of patients with ocular neuromyotonia.
Design: Retrospective cohort.
Methods: Patients diagnosed with ocular neuromyotonia from January 1, 2004, through January 1, 2023, seen at one of the 3 Mayo Clinic sites in Rochester, MN, Scottsdale, AZ, and Jacksonville, FL, comprised the study population.
Disease Modulation Versus Modification: A Call for Revised Outcome Metrics in the Treatment of Thyroid Eye Disease.
Ophthalmic Plast Reconstr Surg
March 2024
Purpose: This perspective introduces the concepts of disease-modulating and -modifying therapy for thyroid eye disease and offers novel metrics for therapeutic outcomes.
Methods: A focused literature review was performed.
Results: Modulators are treatments that suppress disease symptoms whereas modifiers alter the natural history of a disease.