Publications by authors named "J Garcia-Mena"

Archaea have been identified as early colonizers of the human intestine, appearing from the first days of life. It is hypothesized that the origin of many of these archaea is through vertical transmission during breastfeeding. In this study, we aimed to characterize the archaeal composition in samples of mother-neonate pairs to observe the potential vertical transmission.

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Background/aim: Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 infection, manifests a wide range of clinical symptoms ranging from mild to moderate and severe. Host-related factors influence the course of SARS-CoV-2 infection; for instance, the expression of host microRNAs (miRNAs) could influence the progression and complications of COVID-19. This study aimed to determine the expression pattern of endogenous miRNAs in 80 severe COVID-19 patients compared to a group of healthy individuals.

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Article Synopsis
  • The study explored the relationship between specific genetic variations (SNPs) and obesity, involving 396 obese Mexican mestizo individuals and 142 individuals with normal weight.
  • While most SNPs showed no significant link to obesity, the T allele of one SNP was associated with increased obesity risk.
  • The research also found that genetic risk scores interact with waist-to-hip ratio, affecting LDL cholesterol levels, highlighting the importance of considering both genetics and body composition in addressing cardiovascular health.
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The entero-mammary pathway is a specialized route that selectively translocates bacteria to the newborn's gut, playing a crucial role in neonatal development. Previous studies report shared bacterial and archaeal taxa between human milk and neonatal intestine. However, the functional implications for neonatal development are not fully understood due to limited evidence.

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  • The study investigates how the structure of microbial communities in biofilms changes over time when exposed to different concentrations of three specific fungicides (carbendazim, methyl thiophanate, and benomyl) in a bioreactor designed to mimic a barrier against pesticide contamination.
  • A gradient system was used to increase the fungicide levels, allowing researchers to monitor how quickly and effectively the microbial community adapts in terms of removing these pollutants.
  • Results showed that while the community's taxonomic structure significantly changed and did not revert to its original state after exposure to varying fungicide levels, the functional capabilities remained adaptable, showing that the community can still effectively degrade the contaminants even with these shifts.
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