Adrenomedullin Inhibits the Efficacy of Combined Immunotherapy and Targeted Therapy in Biliary Tract Cancer by Disrupting Endothelial Cell Functions.

The global incidence of biliary tract cancer (BTC) is on the rise, presenting a substantial healthcare challenge. The integration of immune checkpoint inhibitors (ICIs) with molecularly targeted therapies is emerging as a strategy to enhance immune responses. However, the efficacy and underlying mechanisms of these treatments in BTC are still largely unexplored.

Heavy metal(loid) contamination in forest fire affected soil and surface water: pollution indices and human health risk assessment.

Forest fires, whether natural or anthropogenic, release and mobilize heavy metal(loids) (HM). Following intense rainfall events, soil-bound HM are transported from soil to surface water through surface runoff, leading to water quality deterioration. Pollution and ecological risk indices are effective tools for assessing HM contamination.

Exploring the scope of inspiratory muscle training in difficult weaning: reflections on the multicentre RCT.

We commend the authors for their insightful study on inspiratory muscle training (IMT) in mechanically ventilated patients with difficult weaning, highlighting the robust use of maximum inspiratory pressure (MIP) as a key outcome. We suggest that a lower baseline maximum inspiratory pressure cutoff could better target patients with significant inspiratory dysfunction, improving the study's precision. Additionally, alternative imputation techniques, such as multiple imputation, could strengthen the handling of missing data.

Effects of electroacupuncture at "Fenglong"(ST40) and "Zusanli"(ST36) on the SIRT1/FOXO1 signaling pathway in non-alcoholic fatty liver disease model rats.

Objectives: To investigate the effects of electroacupuncture (EA) on liver function, lipid metabolism, hepatic histopathology, and the expression of molecules in the SIRT1/FOXO1 signaling pathway in rats with non-alcoholic fatty liver disease (NAFLD), as well as to explore its potential underlying mechanisms.

Methods: A total of 13 SD rats were assigned to the blank group and fed a standard diet. An NAFLD model was established in 43 SD rats through a 12-week high-fat diet.

Impact of an upper limb motion-driven virtual rehabilitation system on residual motor function in patients with complete spinal cord injury： a pilot study.

Background: Assessing residual motor function in motor complete spinal cord injury (SCI) patients using surface electromyography (sEMG) is clinically important. Due to the prolonged loss of motor control and peripheral sensory input, patients may struggle to effectively activate residual motor function during sEMG assessments. The study proposes using virtual reality (VR) technology to enhance embodiment, motor imagery (MI), and memory, aiming to improve the activation of residual motor function and increase the sensitivity of sEMG assessments.