Publications by authors named "J Gameiro"
The gut microbiome as a potential therapeutic target in IgA nephropathy.
Nephrol Dial Transplant
December 2024
Article Synopsis
- Immunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerulonephritis and a major cause of kidney failure, but treatment options are limited.
- The exact mechanisms behind IgAN are not fully understood, but genetic, epigenetic, and environmental influences are believed to contribute significantly.
- Recent research indicates a strong connection between the gut microbiome and the development of IgAN, suggesting it could be a potential target for new treatment strategies.
Introduction: Rituximab (RTX) has been reported as an effective treatment alternative in primary forms of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) associated with steroid dependence and frequent relapses. However, the optimal RTX regimen and the outcomes of further doses of RTX remain unclear. This study aimed to evaluate the use of induction and maintenance RTX therapy for adults with primary podocytopathies.
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