Publications by authors named "J Gabel"
Background: Substandard and falsified (SF) medicines are a serious threat to public health in low- and middle-income countries (LMICs). Visual inspection of medicines and screening analysis using the Global Pharma Health Fund (GPHF)-Minilab are important in medicine quality surveillance in low-resource settings.
Methods: Recently, 260 medicine samples from Nigeria had been investigated for assay and dissolution according to the United States Pharmacopeia (USP).
Introduction: The COVID-19 pandemic overwhelmed health systems, resulting in a surge in excess deaths. This study clustered countries based on excess mortality to understand their response to the pandemic and the influence of various factors on excess mortality within each cluster.
Materials And Methods: This ecological study is part of the COVID-19 MORtality (C-MOR) Consortium.
Article Synopsis
- Researchers developed a predictive model called the Pre-ECPR score to enhance patient selection for extracorporeal cardiopulmonary resuscitation (ECPR), which currently only has a favorable outcome rate of about 20%.
- The study analyzed data from 120 normothermic ECPR patients at a single hospital and found that the Pre-ECPR score, using various health indicators, outperformed existing selection criteria from the Extracorporeal Life Support Organization (ELSO).
- The Pre-ECPR score achieved a strong predictive ability (AUC of 0.87) for identifying patients likely to have good outcomes, significantly boosting the chances of successful ECPR treatment over traditional methods.
Achieving universal access to affordable medicines and at the same time ensuring the quality of medicines presents a challenge, especially in low- and middle-income countries. Here, the relationship between medicine prices and medicine quality was investigated in three African countries. From different types of health facilities and medicine vendors, 711 samples of 18 different essential medicines were purchased and analyzed for quality (assay and dissolution) according to the United States Pharmacopeia.
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- This study analyzed cause-specific mortality rates during the COVID-19 pandemic in 12 countries, focusing on respiratory diseases, pneumonia, cardiovascular disease (CVD), and cancer in 2020 and 2021.
- It found significant reductions in mortality from respiratory diseases and pneumonia in most countries, although some like Georgia and Ukraine saw excess deaths from these causes.
- The research also indicated that stringent control measures helped lower excess mortality rates, while a higher incidence of COVID-19 negatively impacted certain types of mortality, particularly for cancer in 2021.