Mode-resolved optical frequency comb fixed point localization via dual-comb interferometry.

We describe improved methods for locating the fixed point of an optical frequency comb. Two continuous-wave lasers are locked to a reference frequency comb and track the optical phase of a second comb-under-test (CUT) at two points separated by approximately 1.6 THz.

Extreme LDL-C concentration is associated with increased cardiovascular disease in women with homozygous familial hypercholesterolemia.

Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disease of low-density lipoprotein cholesterol (LDL-C) metabolism. Despite the devastating effect of this disease on atherosclerotic cardiovascular health, the disease phenotype and severity are more heterogeneous than previously thought. The predictors of atherosclerotic cardiovascular disease (ASCVD) in HoFH patients have never been systematically studied.

Prevention and Management of Cardiovascular Disease in Primary Care: A Comment on the PEER Simplified Lipid Guideline.

Background: In Canada, 2 guidelines provide guidance for the management of dyslipidemia. The Patients, Experience, Evidence, Research simplified lipid guidelines, intended for primary care practitioners, and the Canadian Cardiovascular Society guidelines, intended for all practitioners, are based on differing methodologies with distinct priorities and preferences. The disparate approaches may contribute to confusion among family practitioners and their co-managed patients, with the potential for compromised care, differing standards for training in the fundamentals of lipidology, and differing criteria that might be used in practice audits to evaluate quality of care.

Graphics card-based real-time processing for dual comb interferometry.

The technique of performing interferometry with two optical frequency combs is used by an increasing number of research groups and even for field deployed commercial applications. Real-time interferogram acquisition, correction, and averaging are, however, still not broadly accessible. This limits the deployment and wider adoption of this high resolution, high sensitivity technique.

Sex differences in treatment of familial hypercholesterolaemia: a meta-analysis.

Background And Aims: Familial hypercholesterolaemia (FH) is a highly prevalent monogenic disorder characterized by elevated LDL cholesterol (LDL-C) levels and premature atherosclerotic cardiovascular disease. Sex disparities in diagnosis, lipid-lowering therapy, and achieved lipid levels have emerged worldwide, resulting in barriers to care in FH. A systematic review was performed to investigate sex-related disparities in treatment, response, and lipid target achievement in FH (PROSPERO, CRD42022353297).