Host size overrides maternal effects on the development of a secondary hyperparasitoid wasp.

Unraveling the numerous factors that drive phenotypic variation in trait expression among animals has long presented a significant challenge. Whereas traits like growth and adult size are often heritable and are passed on from one generation to the next, these can be significantly affected by the quality and quantity of resources provided by one or both parents to their offspring. In many vertebrates, such as birds and mammals, parents raise their young until adult, providing food, shelter, and protection.

Secondary lesions and sensitivity to signaling inhibitors in iAMP21 acute lymphoblastic leukemia.

Intrachromosomal amplification of chromosome 21 (iAMP21) B-cell precursor acute lymphoblastic leukemia (BCP-ALL) in children is a high-risk subtype for which targeted drugs are lacking. In this study, we determined the frequency of secondary lesions in 28 iAMP21 BCP-ALL patient samples and investigated cellular sensitivity for candidate-targeted drugs. iAMP21 was enriched in aberrations (10.

Integrated artificial neurons from metal halide perovskites.

Hardware neural networks could perform certain computational tasks orders of magnitude more energy-efficiently than conventional computers. Artificial neurons are a key component of these networks and are currently implemented with electronic circuits based on capacitors and transistors. However, artificial neurons based on memristive devices are a promising alternative, owing to their potentially smaller size and inherent stochasticity.

Pharmacokinetic exposure and treatment outcomes of lenvatinib in patients with renal cell carcinoma and differentiated thyroid carcinoma.

Purpose: After initial approval of lenvatinib for radioiodine-refractory differentiated thyroid cancer (DTC), it has also shown promising outcomes in among others metastatic renal cell carcinoma (mRCC). Given that trial populations typically do not represent routine clinical care populations, questions arise about how applicable trial outcomes are in clinical practice. This study aims to compare the pharmacokinetics (PK), toxicity patterns, and survival data of lenvatinib in a real-world cohort with DTC and mRCC to those observed in pivotal clinical trials.

Class of nonlinear filtering and windowing methods for image processing and reconstruction.

Linear digital filters are at the core of image reconstruction and processing for many coherent optical imaging techniques, such as digital holography (DH) or optical coherence tomography (OCT). They can also be efficiently implemented using fast Fourier transform (FFT) with appropriate transfer/filter functions that operate in the frequency domain. However, even with optimal filter design, they suffer from side effects such as sidelobe generation or resolution limitations, e.