Publications by authors named "J G Yanuk"
Article Synopsis
- The study examines how various types of DNA, including double-stranded and plasmid DNA, interact with a specific rhenium complex known as Reptr.
- The researchers utilized spectroscopic techniques and imaging methods like electrophoresis and AFM microscopy to analyze changes in DNA structure after these interactions.
- Results indicate that these rhenium complexes can alter DNA structures, either by direct interaction that induces relaxation or through photoinduced cross-linking, with the extent of damage influenced by the types of co-ligands in the complex.
Harmaline (1) and harmalol (2) represent two 3,4-dihydro-β-carboline (DHβCs) most frequently reported in a vast number of living systems. Fundamental aspects including the photosensitizing properties, cellular uptake, as well as the cyto- and phototoxicity of 1 and 2 were investigated herein. The molecular basis underlying the investigated processes are elucidated.
View Article and Find Full Text PDFToxoplasmosis is one of the most prevalent and neglected zoonotic global diseases caused by . The current pharmacological treatments show clinical limitations, and therefore, the search for new drugs is an urgent need in order to eradicate this infection. Due to their intrinsic biological activities, β-carboline (βC) alkaloids might represent a good alternative that deserves further investigations.
View Article and Find Full Text PDFPhotodynamic therapy (PDT) is an emerging clinical treatment currently being used against a wide range of both cancerous and noncancerous diseases. The search for new active photosensitizers as well as the development of novel selective delivery systems are the major challenges faced in the application of PDT. We investigated herein three chloroharmine derivatives (6-, 8- and 6,8-dichloroharmines) with quite promising intrinsic photochemical tunable properties and their ability to photoinduce DNA damage in order to elucidate the underlying photochemical mechanisms.
View Article and Find Full Text PDFIn the present work, we have evaluated the effect of three different types of radiation: UVC (254±5nm), UVA (365±20nm) and visible (420±20nm) on different morphological and biological functions of Toxoplasma gondii tachyzoites. Briefly, UVC and UVA showed an inhibitory effect on parasite invasion in a dose-dependent manner. UVC showed the strongest effect inducing both structural damage (antigens) and functional inhibition (i.
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