IFN-γ signaling links ventriculomegaly to choroid plexus and ependyma dysfunction following maternal immune activation.

Maternal immune activation (MIA) is a principal environmental risk factor contributing to autism spectrum disorder (ASD) and can be causally linked to ASD symptoms. In our study, we found that MIA triggered by poly (I: C) injection caused ventriculomegaly in offspring due to the dysfunction of the choroid plexus (Chp) and ependyma. We subsequently identified a sustained enhancement of interferon-γ (IFN-γ) signaling in the brain and serum of MIA offspring.

Establishment of an efficacy-oriented quality grading framework for herbal medicines: Phyllanthus emblica as an example.

Ethnopharmacological Relevance: Quality control is a powerful method for ensuring the effectiveness and safety of herbal medicines. Phyllanthus emblica L. fruit (PE) has been extensively used in both Ayurvedic and traditional Chinese medicine.

Functional identification of mango MiEXPLA1a2 and MiEXPA4e1 genes in transgenic Arabidopsis and tomato.

Expansin (EXP) is an intrinsic regulator of plant cell expansion, and have been shown to play a role in each stages of plant growth and development. But has not yet been fully studied in mango. In this experiment, two pairs of homologous genes MiEXPA1s and MiEXPA4s were firstly excavated from mango genome.

The competitive mediating role of basal metabolic rate in the association between polycyclic aromatic hydrocarbon exposure and depression risk.

Background: The effect of basal metabolic rate (BMR) on depression was unclear. This study investigated the potential role of BMR in the association of polycyclic aromatic hydrocarbons (PAHs) exposure and depression.

Methods: The study based on the National Health and Nutrition Examination Survey (NHANES).