The study examines how impaired liver function affects the toxicity of the anticancer drug paclitaxel, specifically focusing on hematological complications, dose modifications, and overall survival rates in cancer patients.
It analyzes data from 569 patients treated at the University Medical Centre Utrecht between 2011 and 2022, comparing those with normal and impaired liver function based on specific medical criteria.
Results show that patients with liver impairment experienced significantly higher risks of severe neutropenia and leukopenia, required more dose modifications, and had poorer overall survival in cases of inoperable esophageal and advanced ovarian cancers.
Cigarette smoking negatively affects total joint arthroplasty outcomes, leading to higher pain relief needs, increased mortality, and slower healing.
Electronic cigarettes, a popular alternative among smokers, have not been thoroughly studied for their effects on joint surgery outcomes, prompting this review for insights.
The findings suggest that electronic cigarettes may harm bone health, weaken the immune system, hinder wound healing, and extend hospital stays, necessitating closer monitoring during the perioperative period.