Sex Offender Recidivism: Some Lessons Learned From Over 70 Years of Research.

Sex offender recidivism (SOR) has been the subject of research for over 70 years. Myths, misconceptions, and erroneous conclusions about SOR, however, remain widespread, impeding the development of evidence-based policies aimed at preventing sexual offenses. To address the rich but uneven literature, a comprehensive review was conducted making it possible to provide a contextualized overview of scientific knowledge against the backdrop of methodological issues, challenges, and shortcomings.

What do you fantasize about? An exploratory factor analysis of minor attracted person's sexual fantasies.

Current knowledge on the sexual fantasies of minor attracted persons (MAPs) is primarily focused on these individuals' attraction to minors. Furthermore, MAPs' sexual fantasies are often perceived as revolving systematically around scenarios involving a minor. However, this raises the question of whether their sexual fantasies extend beyond minors.

Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.

Cellular senescence, a stress-induced stable proliferation arrest associated with an inflammatory senescence-associated secretory phenotype (SASP), is a cause of aging. In senescent cells, cytoplasmic chromatin fragments (CCFs) activate SASP via the anti-viral cGAS/STING pathway. Promyelocytic leukemia (PML) protein organizes PML nuclear bodies (NBs), which are also involved in senescence and anti-viral immunity.

HIV-1 and methamphetamine co-treatment in primary human astrocytes: TAARgeting ER/UPR dysfunction.

Objectives: Human immunodeficiency virus 1 (HIV-1) can invade the central nervous system (CNS) early during infection and persist in the CNS for life despite effective antiretroviral treatment. Infection and activation of residential glial cells lead to low viral replication and chronic inflammation, which damage neurons contributing to a spectrum of HIV-associated neurocognitive disorders (HAND). Substance use, including methamphetamine (METH), can increase one's risk and severity of HAND.