Alteration of methylation pattern and gene expression of FTO, PPARγ and Slc2a4 on pre-diabetes-induced BALB/c mice.

T2DM is a serious global health problem and usually caused by unhealthy diet, such diet with high carbohydrate or monosodium glutamate (MSG). In this study, we used the T2DM mice (BALB/c) model by exposing the mice with foods high in carbohydrate (HCD) or MSG (HMD) to determine the changes in molecular expression and methylation pattern of genes correlated to the development of T2DM. The data including clinical data, i.

Potential Utilisation of Pod Husk Extract: Protective Capability Evaluation Against Pollution Models and Formulation into Niosomes.

L. beans have long been used for food and medicinal purposes. However, up to 52%-76% of L.

Laboratory-Based Correlative Soft X-ray and Fluorescence Microscopy in an Integrated Setup.

Correlative microscopy is a powerful technique that combines the advantages of multiple imaging modalities to achieve a comprehensive understanding of investigated samples. For example, fluorescence microscopy provides unique functional contrast by imaging only specifically labeled components, especially in biological samples. However, the achievable structural information on the sample in its full complexity is limited.

Phenylalanine Residues Are Very Rapidly Damaged by Nitrate Radicals (NO ⋅) in an Aqueous Environment.

Kinetic studies revealed that nitrate radicals (NO ⋅), which are formed through reaction of the noxious air pollutants nitrogen dioxide (NO ⋅) and ozone (O ), very rapidly oxidize phenylalanine residues in an aqueous environment, with overall rate coefficients in the 10 -10  M  s range. With amino acids and dipeptides as model systems, the data suggest that the reaction proceeds via a π-complex between NO ⋅ and the aromatic ring in Phe, which subsequently decays into a charge transfer (CT) complex. The stability of the π-complex is sequence-dependent and is increased when Phe is at the N terminus of the dipeptide.

Damage of amino acids by aliphatic peroxyl radicals: a kinetic and computational study.

Absolute second-order rate coefficients for the reaction of the N- and C-protected amino acids tyrosine (Tyr), tryptophan (Trp), methionine (Met) and proline (Pro) with triethylamine-derived aliphatic peroxyl radical TEAOO˙, which was used as a model for lipid peroxyl radicals, were determined using laser flash photolysis. For Ac-Tyr-OMe a rate coefficient of 1.4 × 10 M s was obtained, whereas the reactions with Ac-Trp-OMe and Ac-Met-OMe were slower by a factor of 4 and 6, respectively.