Background: Post-kala-azar dermal leishmaniasis (PKDL) appears as a rash in some individuals who have recovered from visceral leishmaniasis caused by Leishmania donovani. Today, basic knowledge of this neglected disease and how to predict its progression remain largely unknown.
Methods And Findings: This study addresses the use of several biochemical, haematological and immunological variables, independently or through unsupervised machine learning (ML), to predict PKDL progression risk.
Bovine mastitis, a prevalent disease, is often attributed to staphylococci species. These microorganisms can express a diverse array of virulence genes and have the capability to form biofilms, establishing a robust defense against antimicrobials and host immune responses. In this study, we analyzed 191 spp.
View Article and Find Full Text PDFThe interplay between delocalization and repulsive interactions can cause electronic systems to undergo a Mott transition between a metal and an insulator. Here we use neural network hidden fermion determinantal states (HFDS) to uncover this transition in the disordered, fully connected Hubbard model. While dynamical mean-field theory (DMFT) provides exact solutions to physical observables of the model in the thermodynamic limit, our method allows us to directly access the wave function for finite system sizes well beyond the reach of exact diagonalization.
View Article and Find Full Text PDFBinge alcohol use is increasing among aged adults (>65 years). Alcohol-related toxicity in aged adults is associated with neurodegeneration, yet the molecular underpinnings of this age-related sensitivity to alcohol are not well described. Studies utilizing rodent models of neurodegenerative disease reveal heightened activation of Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and Nod like receptor 3 (NLRP3) mediate microglia activation and associated neuronal injury.
View Article and Find Full Text PDFBackground: There seems to be an interdependency of superficial structures on deeper layers, so that aging-related changes in 1 layer may lead to changes to the adjacent layers. Following the same rationale, treatment of 1 area may influence other neighboring aesthetic units. A more holistic approach would encompass soft-tissue repositioning and regenerative biostimulation, aiming for improvement of skin quality by increasing skin's collagen content.
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