Publications by authors named "J G Laufer"
Article Synopsis
- Fluorescing proteins that emit in the near-infrared region, particularly engineered phytochromes, are vital for biomedicine and life sciences, enabling in vivo monitoring of biological systems.
- The study focuses on two minimal phytochromes, miRFP670nano3 and miRFP718nano, examining how their structural characteristics affect the fluorescence of the linked biliverdin chromophore.
- Results indicate that the biliverdin is deprotonated at specific pyrrole rings in both proteins, with differing rates of proton exchange due to their structural dynamics, ultimately influencing their fluorescent efficiency.
Over the past decade, SLN mapping has become increasingly important in cervical cancer surgery. ICG is the most commonly used tracer due to its high bilateral detection rates, ease of use, and safety. However, there is no consensus on the optimal ICG dose, leading to variability in outcomes.
View Article and Find Full Text PDFDifferent tracers for sentinel node detection in gynecologic oncology.
Curr Opin Oncol
September 2024
Purpose Of Review: In the past decade, sentinel lymph node (SLN) mapping has progressively substituted full lymphadenectomies in gynecologic oncology. In this article, we review the most relevant and the latest literature on this topic.
Recent Findings: In endometrial and cervical cancer, the current evidence further support the value of indocyanine green (ICG) as tracer of choice for SLN mapping.
Objective: To report the first uterine transposition for fertility preservation in a patient with vulvar cancer.Case: A 26-year-old nulliparous patient with stage IIIB vulvar cancer, which was resected with adequate margins and bilateral inguinofemoral lymphadenectomy.Laparoscopic transposition of the uterus to the upper abdomen, outside of the scope of radiation was performed to preserve fertility and ovarian function.
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