Publications by authors named "J G Kleinman"
Article Synopsis
- The study explores the biological differences linked to PTSD by examining DNA methylation changes in blood, suggesting they could indicate susceptibility or effects of trauma.
- Conducted by the Psychiatric Genomics Consortium, the research included nearly 5,100 participants to identify specific genetic markers associated with PTSD.
- Results showed 11 significant CpG sites related to PTSD, with some also showing correlations between blood and brain tissue methylation, highlighting their potential role in understanding PTSD biology.
Eating disorders (ED) and obsessive-compulsive disorder (OCD) exhibit significant clinical and genetic overlap, yet their shared molecular mechanisms remain unclear. We conducted a transcriptomic investigation of the dorsolateral prefrontal cortex (DLPFC) and caudate from 86 controls, 57 ED, and 27 OCD cases. ED was associated with robust differentially expressed genes (DEGs): 102 DEGs the DLPFC and 222 in the caudate (FDR < 1%) and replicated in an independent cohort.
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- * Researchers focused on five subdivisions of the primate amygdala in macaques, baboons, and humans, identifying distinct types of excitatory and inhibitory neurons, including specific interneurons.
- * Findings reveal the molecular diversity of amygdalar neuron types, which may enhance current understanding of how these brain circuits affect cognition and mental health, particularly in relation to nonhuman primate models.
Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex.
Biol Psychiatry Glob Open Sci
November 2024
Background: Alcohol use disorder (AUD) has a profound public health impact. However, understanding of the molecular mechanisms that underlie the development and progression of AUD remains limited. Here, we investigated AUD-associated DNA methylation changes within and across 2 addiction-relevant brain regions, the nucleus accumbens and dorsolateral prefrontal cortex.
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- Excessive alcohol consumption is a major preventable cause of death, prompting a study on the genetic factors related to alcohol use disorder (AUD) using brain tissues from deceased individuals with and without AUD.! -
- Researchers analyzed gene expression in two brain regions (nucleus accumbens and dorsolateral prefrontal cortex) and found 476 differentially expressed genes (DEGs) linked to AUD, with some connected to problematic drinking habits.! -
- The study also identified potential drug compounds that could target these DEGs, suggesting opportunities for repurposing existing medications to better treat AUD.!