Publications by authors named "J G Hauptman"
Diffuse intrinsic pontine glioma (DIPG) is a fatal central nervous system (CNS) tumor that confers a median survival of 11 months. As B7-H3 is expressed on pediatric CNS tumors, we conducted BrainChild-03, a single-center, dose-escalation phase 1 clinical trial of repetitive intracerebroventricular (ICV) dosing of B7-H3-targeting chimeric antigen receptor T cells (B7-H3 CAR T cells) for children with recurrent or refractory CNS tumors and DIPG. Here we report results from Arm C, restricted to patients with DIPG.
View Article and Find Full Text PDFObjective: Functional MRI (fMRI) helps with the identification of eloquent cortex to assist with function preservation in patients who undergo epilepsy surgery. Language and memory tasks can even be used effectively in clinically involved pediatric patients. Most pediatric studies report on English speaking-only cohorts from English-dominant countries, yet languages other than English (LOEs) are increasingly prevalent in countries such as the US.
View Article and Find Full Text PDFPurpose: This Hydrocephalus Clinical Research Network (HCRN) study had two aims: (1) to compare the predictive performance of the original ETV Success Score (ETVSS) using logistic regression modeling with other newer machine learning models and (2) to assess whether inclusion of imaging variables improves prediction performance using machine learning models.
Methods: We identified children undergoing first-time ETV for hydrocephalus that were enrolled prospectively at HCRN sites between 200 and 2020. The primary outcome was ETV success 6 months after index surgery.
Article Synopsis
- The study aimed to assess whether the COVID-19 pandemic impacted the incidence of pediatric hydrocephalus surgeries, hypothesizing that surgical volumes would remain stable despite the pandemic.
- Data was gathered from ten institutions about hydrocephalus-related surgeries conducted from March 2018 to February 2022, comparing the COVID-19 era to a pre-COVID baseline.
- Results showed no significant overall change in monthly surgeries during the pandemic compared to pre-COVID, but there was a noticeable decline during the initial surge in April 2020, with disparities noted in patient demographics including sex and race.
Article Synopsis
- Shunt infections are a common issue in hydrocephalus treatment via CSF shunts, but the source of the pathogens remains unclear.
- A study examined 13 patients, comparing CSF samples from infection episodes with samples from earlier surgeries to explore if microorganisms existed before infection symptoms appeared.
- The results showed bacteria in 4 infection samples but none in prior samples, indicating a need for better detection methods and more research into potential infection sources like biofilms.