Publications by authors named "J G Grandjean"

Functional magnetic resonance imaging in rodents holds great potential for advancing our understanding of brain networks. Unlike the human community, there remains no standardized resource in rodents for image processing, analysis and quality control, posing significant reproducibility limitations. Our software platform, Rodent Automated Bold Improvement of EPI Sequences, is a pipeline designed to address these limitations for preprocessing, quality control, and confound correction, along with best practices for reproducibility and transparency.

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Hemispheric brain asymmetry is a basic organizational principle of the human brain and has been implicated in various psychiatric conditions, including autism spectrum disorder. Brain asymmetry is not a uniquely human feature and is observed in other species such as the mouse. Yet, asymmetry patterns are generally nuanced, and substantial sample sizes are required to detect these patterns.

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Background: Chronic cough affects around 10 % of the general adult population, impairing all aspects of quality of life.

Research Question: What are the Leicester Cough Questionnaire's psychometric properties?

Study Design And Methods: Electronic searches of PubMed, CINAHL, and ScienceDirect databases were conducted from inception until October 1rst 2022. All full-text articles, published in French or English, aimed at evaluating the LCQ's content validity or psychometric properties were included.

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The subdivisions of the extended cingulate cortex of the human brain are implicated in a number of high-level behaviors and affected by a range of neuropsychiatric disorders. Its anatomy, function, and response to therapeutics are often studied using non-human animals, including the mouse. However, the similarity of human and mouse frontal cortex, including cingulate areas, is still not fully understood.

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Article Synopsis
  • The study investigates the mouse brain's premotor areas, challenging the idea that the secondary motor cortex (M2) is the sole higher-order motor area like in humans.
  • Researchers identified three distinct premotor areas in mice: anterior-lateral motor cortex (ALM), anterior-lateral M2 (aM2), and posterior-medial M2 (pM2), each with unique structural and functional features.
  • The findings suggest that ALM closely resembles the human anterior ventral premotor areas, while aM2 and pM2 share properties with human pre-SMA and cingulate cortex, providing insights into the similarities between the motor systems of humans and mice.
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