Publications by authors named "J G Dowler"
Article Synopsis
- * A mixed-methods, co-design approach will involve young people with diabetes, their families, and health professionals to develop and improve care models, including guidelines, support networks, and training for healthcare providers.
- * The study has received ethical approval and aims to produce valuable insights and practices for enhancing diabetes care that are both age-appropriate and culturally sensitive.
Objective: Our aim in this study was to gain an understanding of the experiences of Aboriginal and Torres Strait Islander young people aged 10 to 25 years with type 2 diabetes (T2D) living in Northern and Central Australia.
Methods: In this qualitative study, we explored participants' experiences of T2D using a social constructionist epistemology and a phenomenologic methodology. Twenty-seven young people participated in semistructured in-depth interviews from 4 primary health-care sites.
Background/aims: To describe clinical and multimodal imaging features in a cohort of choroidal macrovessels.
Methods: Demographics and multimodal imaging features of 16 eyes of 13 patients with choroidal macrovessels were reviewed. The multimodal imaging included colour fundus photography, fundus autofluorescence (FAF), spectral domain enhanced depth imaging optical coherence tomography (OCT), en face OCT, OCT-angiography (OCT-A), B-scan ultrasonography (US), fluorescein angiography (FFA) and indocyanine green angiography (ICGA).
Objective: To determine the incidence, clinical presentation and progress of acute post-streptococcal glomerulonephritis in Central Australia.
Design: Retrospective observational analysis.
Setting: Paediatric inpatient admission at Alice Springs Hospital.
Selective macroautophagy/autophagy-with the help of molecular receptors-captures cargo for lysosomal degradation. Among the best-studied molecular receptors is SQSTM1/p62, a homo-oligomeric ubiquitin binding protein, which binds to both cargo and MAP1LC3B/LC3, a protein important for autophagosome biogenesis. Although the mechanisms underlying interaction of LC3 and SQSTM1 have been extensively studied, very little is known about the size or organization of soluble complexes formed between SQSTM1 and LC3 prior to phagophore (the autophagosome precursor) binding in live cells at the molecular level.
View Article and Find Full Text PDF