Publications by authors named "J G Coghlan"
Background: Avoiding inclination of the glenoid baseplate in reverse shoulder arthroplasty often requires considerable glenoid reaming. It is proposed that the use of a metal wedged baseplate in all patients can achieve neutral inclination with reduced glenoid reaming.
Materials And Methods: A prospective clinical single-centre study with minimum two-year follow-up was carried out.
Objectives: We examined adverse event (AE) reports relating to cabotegravir/rilpivirine (CAB/RPV) in the US FDA Adverse Event Reporting System (FAERS), focusing on therapeutic failure (TF) and non-therapeutic failure (NTF) outcomes.
Methods: FAERS is a database of AE and medication error reports from post-marketing surveillance. The study was granted exempt approval by the Binghamton University Institutional Review Board.
Article Synopsis
- Systemic sclerosis complicated by pulmonary arterial hypertension (SSc-PAH) presents significant risks, and this study aimed to evaluate if exercise-based cardiac assessments could predict patient outcomes better than traditional resting measures.
- Fifty intermediate-risk SSc-PAH patients underwent cardio MRI during exercise, finding that most had normal resting cardiac metrics but that peak exercise indicators, specifically RV indexed end-systolic volume (ESVi), were key for predicting survival.
- The study concluded that exercise CMR could help identify patients at higher risk of mortality, enhancing risk assessment practices even when resting tests appear normal.
Background: In the EDITA trial, patients with systemic sclerosis (SSc) and mild pulmonary vascular disease (PVD) treated with ambrisentan had a significant decline of pulmonary vascular resistance (PVR) but not of mean pulmonary arterial pressure (mPAP) vs. placebo after six months. The EDITA-ON study aimed to assess long-term effects of open label therapy with ambrisentan vs.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how heart size and function, measured through cardiovascular magnetic resonance (CMR), can predict outcomes in patients with pulmonary hypertension associated with systemic sclerosis (SSc-PH).
- Out of 148 SSc-PH patients monitored over a median of 3.5 years, 45% died, with findings indicating that older age, right ventricular dilation, and higher native myocardial T1 values were linked to increased mortality risk.
- Importantly, right ventricular end-systolic volume index (RVESVi) and native T1 were identified as independent predictors of mortality, with specific thresholds set for better patient outcomes, highlighting the significance of myocardial tissue characterization in prognosis.