Purpose: To describe the clinical and histopathologic finding of very limited ophthalmic Wegener granulomatosis (WG).
Methods: Thirteen patients with scleritis, orbitopathy, episcleritis, and panuveitis were studied. They presented without evidence of lung or kidney disease, though eight had sinus involvement.
Objective: This review article is designed to thoroughly familiarize all health care professionals with the history, classification, epidemiology, clinical characteristics, differential diagnosis, diagnostic evaluation (including laboratory-based testing), treatment, and prognosis of botulism. It is especially targeted toward clinical laboratorians and includes a detailed enumeration of the important clinical laboratory contributions to the diagnosis, treatment, and monitoring of patients with botulism. Finally, the bioterrorism potential for botulism is discussed, with an emphasis on the clinical laboratory ramifications of this possibility.
View Article and Find Full Text PDFObjective: To assess the effects of acetic acid iontophoresis on the treatment of calcifying tendinitis of the shoulder.
Design: Double-blind randomized controlled trial.
Setting: Ambulatory academic hospital in Quebec, Canada.
Proc Natl Acad Sci U S A
June 2002
Loss of function of the adenomatous polyposis coli (APC)/Apc tumor suppressor gene occurs early in the etiology of intestinal cancer in mammals. In human colonic tumors, genomic instability is proposed to be associated with tumor initiation by inducing loss of APC function. We have used a mouse model of inherited intestinal cancer (Apc(Min)/+, Min/+) to analyze the earliest stages of tumorigenesis in this organ.
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