Publications by authors named "J G BAER"
Viral meningitis poses a significant clinical challenge due to its rapid onset and potential progression to life-threatening encephalitis. Early detection of treatable viral pathogens such as Herpes simplex virus (HSV), Cytomegalovirus (CMV), and Varicella-zoster virus (VZV) is essential for initiating appropriate therapies. However, multiplex PCRs for the rapid and simultaneous detection of these pathogens are scarce due to the complex PCR design and the elaborate validation process using cerebrospinal fluid samples.
View Article and Find Full Text PDFBackground: Left atrial appendage (LAA) occlusion (LAAO) is performed to prevent LAA thrombus in patients with atrial fibrillation (AF). The risk of device-related thrombus (DRT) on the atrial side of the LAAO device is approximately 4%. Identifying patients at high risk of DRT would enable closer surveillance and more-aggressive anticoagulation to prevent post-LAAO DRT-related stroke.
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- - Abscission is the intentional separation of plant organs, crucial for plant development and reacting to environmental changes; it is regulated in Arabidopsis by the receptor-like kinases HAESA (HAE) and HAESA LIKE-2 (HSL2) that manage the breakdown of connections between floral organs and fruit.
- - The study employs single-cell RNA sequencing to map the gene expression involved in abscission, identifying MKP1 as a negative regulator that sets a necessary threshold for HAE/HSL2 signaling before abscission occurs.
- - The research also reveals different gene expressions in subpopulations of abscission zone cells, with IDA family genes promoting HAE/HSL2 signaling in the distal cells
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is often resistant to therapy. An immune suppressive tumor microenvironment (TME) and oncogenic mutations in have both been implicated as drivers of resistance to therapy. Mitogen-activated protein kinase (MAPK) inhibition has not yet shown clinical efficacy, likely because of rapid acquisition of tumor-intrinsic resistance.
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- Atrial fibrillation (AF) can weaken the left atrial appendage, increasing the risk of stroke, which can be measured through left atrial appendage emptying velocity (LAAev) via transesophageal echocardiogram (TEE).
- A study evaluated factors that lead to reduced LAAev (<30 cm/s) in patients with AF, using logistic regression to create a risk prediction model called the CHIRPM score based on various clinical and echocardiographic traits.
- The model was validated against a dataset, showing that both low and high CHIRPM scores significantly correlated with LAAev levels, offering a new way to assess stroke risk among individuals with AF.