Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression.

The maintenance of stable allograft status in the absence of immunosuppression, known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multi-center, biomarker-strategy design, immunosuppression withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver tissue collected before initiating immunosuppression weaning.

Electromyographic Comparison of Traditional Fitness Machines, Outdoor Fitness Equipment Without Load Selectors, and Outdoor Fitness Equipment with Load Selectors in a Seated Chest Press Exercise in Trained Young Men.

Outdoor fitness equipment (OFE) are strength training installations comparable to those found in indoor gyms but are located outdoors with greater accessibility. However, the scientific evidence supporting their effectiveness remains limited. The objective of this study was to analyze and compare the electromyographic (EMG) activity of upper limb muscle groups during the use of a traditional seated chest press (SCP) machine, a classic OFE SCP (OFE-SCP), and a new OFE-SCP featuring a load selector system (BIOFIT-SCP).

Age-dependent differences in FIB-4 predictions of fibrosis in patients with MASLD referred from primary care.

Background: Fibrosis 4 (FIB-4) is widely used to triage patients with metabolic dysfunction-associated steatotic liver disease. Given that age is part of FIB-4, higher scores may be expected in the elderly population. This led to the proposal of using a higher threshold of FIB-4 to triage patients aged ≥65.