Publications by authors named "J Fujita-Yoshigaki"
Objectives: Secretory granules produced by salivary acinar cells accumulate if secretory stimulation is suppressed. Aged and deteriorated secretory granules can cause tissue damage because of abnormal secretion and/or intracellular leakage. To elucidate the deterioration process, we characterized the changes in the stimulus responsiveness of secretory granules using HaloTag technology.
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- This study examined how central sensitization symptoms relate to pain perception in patients with chronic masticatory myofascial pain transitioning from acute to chronic stages.
- Researchers tested 23 patients with myofascial pain and 22 healthy volunteers, measuring pain thresholds and central sensitization using various assessments.
- Results indicated that patients with chronic pain had lower pain thresholds but no correlation between central sensitization scores and pain perception, suggesting that central sensitization might occur before visible symptoms appear.
Parotid glands are exocrine glands that release saliva into the oral cavity. Acinar cells of parotid glands produce many secretory granules (SGs) that contain the digestion enzyme amylase. After the generation of SGs in the Golgi apparatus, they mature by enlarging and membrane remodeling.
View Article and Find Full Text PDFObjective: To identify factors that affect salivary gland recovery, we investigated the expression and function of bone morphogenetic protein 2 (BMP2) in mice.
Materials And Methods: Using a micro clip, mice parotid glands were removed 7 days after the ligation of the unilateral parotid excretory duct. Thereafter, they were weighed and stained with hematoxylin and eosin, and expression was examined via real-time reverse transcription-polymerase chain reaction.
Bone morphogenetic protein (BMP)-1 is expressed by odontoblasts in the dentin-pulp complex. Although the functional effects of BMP-1 on the maturation of various preforms of proteins and enzymes involved in initiating mineralization have been widely observed, how BMP-1 affects cellular molecules remains unknown. We performed a comprehensive analysis of BMP-1-altered glycome profiles and subsequent assays to identify the target glycoproteins in human dental pulp cells (hDPCs) by a glycomic approach.
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