Publications by authors named "J Fujimura"
The everyday harms of structural racism and discrimination, perpetuated through institutions, laws, policies, and practices, constitute social determinants of health, but measures that account for their debilitating effects are largely missing in genetic studies of complex diseases. Drawing on insights from the social sciences and public health, we propose critical methodologies for incorporating tools that measure structural racism and discrimination within genetic analyses. We illustrate how including these measures may strengthen the accuracy and utility of findings for diverse communities, clarify elusive relationships between genetics and environment in a racialized society, and support greater equity within genomics and precision health research.
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- A multicenter retrospective study analyzed 343 children who had renal ultrasounds during their first febrile urinary tract infection (fUTI) from 2013 to 2020, focusing on the effects of sonographic temporary nephromegaly.
- The study found that children with temporary nephromegaly experienced longer fevers and antibiotic treatments, and had higher levels of inflammatory markers and recurrence rates of fUTI compared to those without nephromegaly.
- Additionally, a logistic regression indicated that children with temporary nephromegaly had an increased likelihood of vesicoureteral reflux (VUR), suggesting that nephromegaly may be an early indicator of potential fUTI recurrence and VUR in affected kids
Article Synopsis
- The JPLT3-S study examined the effectiveness of cisplatin (CDDP) monotherapy for young children with standard-risk hepatoblastoma, aiming to reduce treatment toxicity compared to previous studies.
- A total of 38 patients under 3 years old participated, achieving a remarkable 3-year progression-free survival rate of 93.9% and a 100% overall survival rate.
- Despite the positive outcomes, nearly half of the patients experienced late-onset ototoxicity, highlighting a potential side effect of CDDP treatment.
Article Synopsis
- * A total of 90 s-JIA patients and 27 controls with other febrile diseases were included in the study, where the performance of both diagnostic criteria was assessed alongside expert diagnoses and serum IL-18 measurements.
- * Results show that while PRINTO criteria have higher sensitivity but lower specificity than ILAR criteria, combining PRINTO with serum IL-18 levels of ≥ 4,800 pg/mL significantly enhances diagnostic accuracy, achieving the best performance overall.
Article Synopsis
- The study investigates the role of iron in pediatric Immunoglobulin A nephropathy (IgAN) with macrohematuria-induced acute kidney injury (AKI) and its impact on long-term kidney health, noting that a significant percentage of adults with similar conditions develop chronic kidney disease.
- Researchers analyzed renal biopsy samples from 44 children to assess iron deposition and immune cell characteristics, finding extensive iron accumulation in children with both IgAN and AKI.
- The findings suggest that although iron builds up in the kidneys of affected children, their overall kidney function appears to remain stable, indicating a favorable prognosis for pediatric patients with this condition.