Publications by authors named "J Friedewald"
Introduction: Kidney transplantation (KT) in older age is increasingly common as more elderly patients live with end-stage renal disease. Immunosuppression (IS) after KT confers additional risk in aging patients with weakened immune systems. We hypothesized that 1-year mortality among KT recipients aged 70 y and older would be higher in those receiving induction IS with alemtuzumab lymphocyte depletion versus basiliximab interleukin-2 inhibition.
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- The study explores attitudes of living kidney donor candidates of African ancestry toward using the Gia chatbot for Apolipoprotein L1 (APOL1) genetic testing during the donor evaluation process.
- Focus groups with 54 participants revealed that most supported the use of the chatbot prior to clinic visits and expressed interest in APOL1 testing after utilizing the technology.
- However, concerns about testing costs and individual preferences for chatbot usage in healthcare settings emerged as potential barriers to widespread adoption.
Key Points: Peripheral blood biomarkers may have value in monitoring kidney transplant recipients after treatment of acute rejection. The donor-derived cellfree DNA may be more sensitive to identifying antibody-mediated rejection and gene expression profile may be more sensitive to identifying acute cellular rejection.
Background: Persistent rejection is an increasingly recognized barrier to long-term kidney allograft survival.
Article Synopsis
- The study investigates how competing risks, like allograft failure and death with a functioning graft, affect the performance of prognostic models used for kidney transplant recipients.
- The research involves 11,046 kidney transplant recipients across 10 countries, developing models using various regression techniques to predict long-term graft failure while carefully evaluating their accuracy and reliability.
- Results indicate that both standard Cox models and competing risk models provide similar predictions for graft failure, with high concordance indices, confirming their usefulness in clinical settings.