Publications by authors named "J Fric"
Crohn's disease (CD) is marked by recurring intestinal inflammation and tissue injury, often resulting in fibrostenosis and bowel obstruction, necessitating surgical intervention with high recurrence rates. To elucidate the mechanisms underlying fibrostenosis in CD, we analyzed the transcriptome of cells isolated from the transmural ileum of patients with CD, including a trio of lesions from each patient: non-affected, inflamed, and stenotic ileum samples, and compared them with samples from patients without CD. Our computational analysis revealed that profibrotic signals from a subset of monocyte-derived cells expressing CD150 induced a disease-specific fibroblast population, resulting in chronic inflammation and tissue fibrosis.
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- CN-NFAT inhibitors are commonly used drugs to suppress T cell responses but can negatively impact innate immune cells, leading to increased susceptibility to infections.
- This study examined how these inhibitors affect human neutrophils' response to fungi like Candida albicans and Aspergillus fumigatus, revealing significant changes in gene expression related to immune response.
- The presence of CN-NFAT inhibitors reduced the production of key chemokines, impairing neutrophils' ability to attract other immune cells, highlighting the inhibitors' broader effects on immune function.
Article Synopsis
- Multiple sclerosis is a serious disease where the immune system attacks the central nervous system, causing inflammation.
- Scientists found that a substance made by gut bacteria, called indole-3-carboxaldehyde (3-IAld), seems to help with this disease by affecting how the body uses a chemical called tryptophan.
- This process could protect the body and might even lead to new treatments for autoimmune diseases like multiple sclerosis.
COVID-19 manifestation is associated with a strong immune system activation leading to inflammation and subsequently affecting the cardiovascular system. The objective of the study was to reveal possible interconnection between prolongated inflammation and the development or exacerbation of long-term cardiovascular complications after COVID-19. We investigated correlations between humoral and cellular immune system markers together with markers of cardiovascular inflammation/dysfunction during COVID-19 onset and subsequent recovery.
View Article and Find Full Text PDFCommon variable immunodeficiency disorder (CVID) is the most common form of primary antibody immunodeficiency. Due to low antibody levels, CVID patients receive intravenous or subcutaneous immunoglobulin replacement therapy as treatment. CVID is associated with the chronic activation of granulocytes, including an increased percentage of low-density neutrophils (LDNs).
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