Lethal COVID-19 associates with RAAS-induced inflammation for multiple organ damage including mediastinal lymph nodes.

Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying of SARS-CoV-2. Subsets of the 100 top-upregulated genes in nasal swabs are upregulated in the heart, lung, kidney, and liver, but not mediastinal lymph nodes.

Machine learning in knee injury sequelae detection: Unravelling the role of psychological factors and preventing long-term sequelae.

Purpose: This study evaluated the performance of three machine learning (ML) algorithms-decision tree (DT), multilayer perceptron (MLP) and extreme gradient boosting (XGB)-in identifying regular athletes who suffered a knee injury several months to years prior. In addition, the contribution of psychological variables in addition to biomechanical ones in the classification performance of the ML algorithms was assessed, to better identify factors to get back to competitive sport with the lowest possible risk of new knee injury.

Methods: A cohort of 96 athletes, 36 with prior knee injuries, practicing an average of 5.

Effects of a soft back exoskeleton on lower lumbar spine loads during manual materials handling: a musculoskeletal modelling study.

The aim of this study was to append a passive soft back exoskeleton to a validated musculoskeletal model and assess its effectiveness in reducing lumbar loads. Fifteen participants lifted a box, with and without wearing a CORFOR exoskeleton. A full body OpenSim model was used to estimate lumbar joint moments and reaction forces, as well as low back muscles forces.

Single time-point analysis of product and substrate inhibition.

When enzyme inhibition by either the product or excess substrate occurs, it is possible to determine the characteristic kinetic parameters based on [P]/t measurements, even when a large proportion of the substrate is converted. The advantages of various approaches are discussed. Most of them allow a good estimation of the V and K values.