Publications by authors named "J Frand"
Skin pigmentation is paused after sun exposure; however, the mechanism behind this pausing is unknown. In this study, we found that the UVB-induced DNA repair system, led by the ataxia telangiectasia mutated (ATM) protein kinase, represses MITF transcriptional activity of pigmentation genes while placing MITF in DNA repair mode, thus directly inhibiting pigment production. Phosphoproteomics analysis revealed ATM to be the most significantly enriched pathway among all UVB-induced DNA repair systems.
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- Scientists found that men and women react differently to sunlight when it comes to wanting food!
- In both humans and mice, sunlight increases hunger in males, but not in females!
- The study shows that a substance called ghrelin, which makes us feel hungry, is affected by the sunlight and other body chemicals differently in men and women!
Article Synopsis
- Cutaneous melanoma tumors are diverse and show different responses to treatments, highlighting the need for effective molecular biomarkers to better classify and manage the disease.
- The study identifies four melanoma tumor subtypes based on three gene expression patterns: keratin, immune, and melanogenesis, with the latter linked to poorer survival rates.
- Researchers developed a molecular classification tool that uses key genes to predict tumor subtypes, validated with patient samples, aiming to enhance diagnosis and treatment strategies for melanoma.
Background: The effect of weight reduction following bariatric surgery is already well known.
Objectives: To investigate the effects of abdominoplasty on metabolic markers indicative of weight loss.
Methods: The authors prospectively enrolled consecutive obese patients after laparoscopic sleeve gastrectomy.
Background: The use of oral midazolam as premedication to induce anxiolysis before surgical procedures under local anesthesia is widely accepted in plastic surgery. Rhinoplasty performed under local anesthesia is known to generate high levels of perioperative anxiety, thus the use of appropriate premedication is important. Oral midazolam has been shown to be safe in various procedures.
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