Publications by authors named "J Francisco Montiel-Sosa"
Alzheimer's disease (AD) is clinically characterized by a progressive loss of cognitive functions and short-term memory. AD patients present two distinctive neuropathological lesions: neuritic plaques and neurofibrillary tangles (NFTs), constituted of beta-amyloid peptide (Aβ) and phosphorylated and truncated tau proteins. Aβ deposits around cerebral blood vessels (cerebral amyloid angiopathy, CAA) is a major contributor to vascular dysfunction in AD.
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- Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) are both tauopathies, characterized by abnormal tau protein aggregates; AD features a 1:1 ratio of 4-repeat to 3-repeat tau isoforms, while PSP shows a predominance of the 4-repeat isoform.
- The study aimed to compare how pathological tau is processed in PSP compared to AD, utilizing double and triple immunofluorescent labeling techniques analyzed through confocal microscopy.
- Results indicated that phosphorylated tau was similarly abundant in both conditions, but PSP had unique tau truncation patterns and extracellular NFTs that could lead to the identification of distinct biomarkers for differentiating AD from PSP.
The aim of this study was to investigate the viability of ATCC 8042 and ATCC 8014 in a freeze-dried capsules system prepared with sodium alginate and gum arabic using the extrusion technique. The capsules made with alginate 2% (w/v)/gum arabic 2% (w/v) showed higher hardness (7.12 ± 0.
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- Mitochondria are crucial for producing ATP (energy) and regulating cellular metabolism, so changes in mitochondrial DNA (mtDNA) can lead to diseases.
- Kearns Sayre syndrome (KSS) is one such disease, characterized by various large-scale deletions in mtDNA, first identified in 1958.
- This study analyzed mtDNA from three KSS patients, uncovering previously known deletions in two cases and a new deletion in one, providing insights into the genetic variations associated with KSS.
Article Synopsis
- * A Mexican patient with KSS was identified, featuring a new deletion of 7629 base pairs, with a high level of heteroplasmy (85%), which hasn't been documented before.
- * Genetic analysis showed specific patterns of repeats around the deletion and suggested that the patient might belong to a Native American lineage known as haplogroup C4c.