Study of Histotripsy With Subsequent Heating on In Vitro VX2 Cancer Cells.

Objective: Focused ultrasound has emerged as a precise and minimally invasive modality for effective cancer treatment. In this study, we propose a novel method that integrates the mechanical effects of focused ultrasound, known as histotripsy, with heating to enhance both the immediate and sustained cytotoxic effects on cancer cells.

Methods: Our investigation focused on VX2 cancer cells in suspension, examining five experimental groups: blank control, negative control, heating alone, histotripsy alone, and histotripsy with subsequent heating.

Exploring Demographic Disparities in Private Well Water Testing in North Carolina.

The natural, built, and social environments shape drinking water quality supplied by private wells. However, the combined effects of these factors are not well understood. Using North Carolina as a case study, we (i) estimate the demographic characteristics of the private well population; (ii) evaluate representation in well testing records; and (iii) demonstrate how spatial scale influences knowledge of well-using household demographics and representation in testing.

Machine learning models based on FEM simulation of hoop mode vibrations to enable ultrasonic cuffless measurement of blood pressure.

Blood pressure (BP) is one of the vital physiological parameters, and its measurement is done routinely for almost all patients who visit hospitals. Cuffless BP measurement has been of great research interest over the last few years. In this paper, we aim to establish a method for cuffless measurement of BP using ultrasound.

Safety, Ergonomics and Patient Centered Point-of-Care Ultrasound.

Ultrasound imaging is a safe diagnostic tool that has become ubiquitous, in part due to its portability, effectiveness, and safety record. The latter is aided be adherence to regulatory limits, safety guidelines, and the "as low as reasonably achievable" principle. Operators receive feedback on potential tissue heating and mechanical effects through output display standard that shows the thermal index and mechanical index.

LCoRL Regulates Growth and Metabolism.

Genome-wide association studies (GWAS) in humans and livestock have identified genes associated with metabolic traits. However, the causality of many of these genes on metabolic homeostasis is largely unclear due to a lack of detailed functional analyses. Here we report ligand-dependent corepressor-like (LCoRL) as a metabolic regulator for body weight and glucose homeostasis.