Publications by authors named "J Fourgeaud"
Background: A Parvovirus B19 (B19V) outbreak has been reported in Europe in 2023-2024. The aims of this study were 1) to describe the incidence of primary cases from 2012 to 2024 in one French hospital 2) to analyze the genome of 2023 strains 3) to identify virological profiles according to the clinical presentations of B19V infection.
Methods: The incidence of B19V primary cases was studied through an interrupted time-series analysis.
Article Synopsis
- - Enteric viruses are a leading cause of acute gastroenteritis globally, particularly affecting children and the elderly, and can also lead to severe neurological diseases like poliomyelitis.
- - Understanding of immune responses to these viruses is primarily derived from animal studies, although vaccines (like those for poliovirus and rotavirus) have advanced our knowledge, particularly regarding protective immunity.
- - Research on Inborn Errors of Immunity highlights the importance of antibodies, showing that individuals with inadequate antibody production are more susceptible to prolonged enteric viral infections and related neurological issues due to the role of B cells and immunoglobulins in viral control.
Background: The treatment of congenital cytomegalovirus (CMV) infection is usually administered to neonates after birth; however, it can be anticipated during the prenatal period by treating pregnant women in order to reduce the severity of the congenital disease. The most commonly used treatment for CMV during pregnancy is valaciclovir; however, valganciclovir has a higher potency against CMV and is the first choice for neonates with congenital CMV disease.
Objectives: We investigated neonatal and maternal safety of tertiary prevention in infected fetuses showing ultrasound features of infection using valganciclovir.
Corrigendum to "Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI)" [The Lancet Regional Health - Europe 40 (2024) 100892].
Lancet Reg Health Eur
July 2024
[This corrects the article DOI: 10.1016/j.lanepe.
View Article and Find Full Text PDFFMS-related tyrosine kinase 3 ligand (FLT3L), encoded by FLT3LG, is a hematopoietic factor essential for the development of natural killer (NK) cells, B cells, and dendritic cells (DCs) in mice. We describe three humans homozygous for a loss-of-function FLT3LG variant with a history of various recurrent infections, including severe cutaneous warts. The patients' bone marrow (BM) was hypoplastic, with low levels of hematopoietic progenitors, particularly myeloid and B cell precursors.
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