Publications by authors named "J Fortun"
Background: Invasive candidiasis/candidemia (IC/C) is associated with a substantial health economic burden driven primarily by prolonged hospital stay. The once-weekly IV echinocandin, rezafungin acetate, has demonstrated non-inferiority to caspofungin in the treatment of IC/C. This paper reports a post hoc pooled exploratory analysis of length of stay (LoS) for hospital and intensive care unit (ICU) stays in two previously published clinical trials (ReSTORE [NCT03667690] and STRIVE [NCT02734862], that compared rezafungin with daily IV caspofungin (stable patients in the caspofungin group who met relevant criteria could step down to fluconazole after 3 days or more).
View Article and Find Full Text PDFIntroduction: Sedating and anesthetic drugs are widely used in clinical practice; however, relevant teaching remains underrepresented in undergraduate medical education. We developed a 2-hour flipped classroom activity integrating foundational science topics, evidence-based medicine, and clinical reasoning on anesthetic pharmacology for preclinical medical students.
Methods: Presession, second-year medical students reviewed a study guide and completed a readiness assessment.
Background: Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with coronavirus disease 2019 (COVID-19). NEPTUNO, a phase III, multicenter, randomized, controlled trial, was designed to evaluate the efficacy and safety of plitidepsin in the management of moderate COVID-19 in hospitalized adult patients.
Methods: Included patients had documented severe acute respiratory syndrome coronavirus 2 infection, required oxygen therapy, and had adequate organ function.
Article Synopsis
- * A working group has developed new consensus recommendations for CMV management in SOT recipients, integrating recent advancements in cell-mediated immunity monitoring.
- * These recommendations were rated for their evidence strength and quality using the GRADE system and were formally endorsed by a consensus meeting of experts.
How can we optimize the diagnostic and therapeutic approach to pneumonia? Expert opinion-based recommendations.
Enferm Infecc Microbiol Clin (Engl Ed)
October 2024
Article Synopsis
- - Pneumonia is a common and serious infectious disease, significantly impacting mortality rates and healthcare resources.
- - The OPENIN Group, comprised of specialists in Infectious Diseases and Microbiology, focuses on improving clinical processes related to pneumonia diagnosis and treatment through a review of existing scientific research.
- - The group's initial meeting in October 2023 addressed optimizing pneumonia diagnosis, possibly reducing antibiotic treatment duration, and exploring the use of immunomodulatory strategies like steroids, leading to expert recommendations based on their findings.