Publications by authors named "J Fortier"
Uterine dendritic cells (uDCs) are critical for endometrial function, yet their origin, molecular characteristics, and specific roles during the pre- and post-implantation periods in the human endometrium remain largely unknown. The complexity of the endometrial environment makes defining the contributions of uDCs subtypes challenging. We hypothesize that distinct uDC subsets carry out specialized functions, and that resident progenitor DCs generate these subtypes.
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- Dendritic cells (DCs) are crucial in understanding how HIV infects individuals, particularly in the female genital tract, which is a primary entry point for the virus.
- Researchers studied different types of genital DCs at the single cell level to see how they respond to HIV right after exposure.
- They discovered distinct DC subsets with unique responses: CD14+ DCs primarily triggered an antimicrobial response, while CD1c+ DC2s activated inflammasome pathways and interferon responses, highlighting potential strategies for preventing HIV infection.
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- Multiple Myeloma (MM) is an incurable cancer affecting plasma cells, with over 35,000 new cases diagnosed each year in the U.S., leading to frequent relapses and limited treatment options.
- Researchers used transcriptome sequencing to compare newly diagnosed MM patients with short progression-free survival (PFS) to those with longer PFS, identifying 157 lncRNAs associated with poor outcomes, particularly focusing on one specific lncRNA.
- The study found that the overexpression of this lncRNA enhances cell viability and decreases apoptosis, while its knockdown has the opposite effect, and targeted therapies using antisense oligonucleotides showed potential in reducing cell viability and promoting apoptosis in MM cells.
Rationale: Most child well-being and childhood adversity research is informed by proxy informants such as parents or teachers rather than children and youth. This may be due to concerns about perceived sensitivity, challenges accessing and engaging with children in research, ethical considerations, and apprehensions about causing undue harm and distress. This study aimed to understand adolescents' identification of, and reactions to, questions in the context of participating in a survey of well-being and adversity.
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- A 54-year-old woman was admitted with recurrent abdominal pain and new chest pain, leading to the discovery of a thoracic aortic aneurysm, suspected to involve intramural hematoma or aortitis.
- Initial conservative treatment was followed by surgical intervention after imaging suggested intramural hematoma, but surgery revealed severe aortitis without hematoma, indicating complex diagnostic challenges.
- Further examination identified IgG4-related disease linked to chronic lymphocytic leukemia (CLL), highlighting the need for a multidisciplinary approach and various diagnostic methods to accurately assess aortic conditions.