Hypersensitivity to intravenous iron: classification, terminology, mechanisms and management.

Intravenous (IV) iron therapy is widely used in iron deficiency anaemias when oral iron is not tolerated or ineffective. Administration of IV-iron is considered a safe procedure, but severe hypersensitivity reactions (HSRs) can occur at a very low frequency. Recently, new guidelines have been published by the European Medicines Agency with the intention of making IV-iron therapy safer; however, the current protocols are still non-specific, non-evidence-based empirical measures which neglect the fact that the majority of IV-iron reactions are not IgE-mediated anaphylactic reactions.

Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management.

Intravenous iron is widely used for the treatment of iron deficiency anemia when oral iron is inappropriate, ineffective or poorly tolerated. Acute hypersensitivity reactions during iron infusions are very rare but can be life-threatening. This paper reviews their frequency, pathogenesis and risk factors, and provides recommendations about their management and prevention.

[Attitudes to the use of a decision support method when introducing new medical technology at the University Hospital of Copenhagen].

Introduction: The aims of this investigation were to describe the development of a structured decision support information method at a major Danish university hospital and to present the results of a quantitative organisational evaluation of this method for integrated decision making at many levels of the management hierarchy.

Materials And Methods: The results of more than five years' development of the decision support method are described. Quantitative analyses of attitudes to the method included a survey of satisfaction with the method in general along with specific questions concerning its perceived effect on administrative and organisational success parameters.