Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial.

Human epidermal growth factor receptor 2 (HER2, also known as ERBB2) signaling promotes cell growth and differentiation, and is overexpressed in several tumor types, including breast, gastric and colorectal cancer. HER2-targeted therapies have shown clinical activity against these tumor types, resulting in regulatory approvals. However, the efficacy of HER2 therapies in tumors with HER2 mutations has not been widely investigated.

Graduate student literature review: Integrating concepts of animal welfare and health-related quality of life for pre-weaned dairy calves.

Dairy calf welfare assessment tools focusing on the pre-weaning period have been proposed in recent research. Despite the existence of these tools, assessing the welfare and health-related quality of life (HRQoL) of dairy calves remains challenging. These difficulties may stem from the complexity of assessing all dimensions of calf welfare and the validity, reliability, and feasibility of the indicators used in assessment tools.

Perceptions and experiences of directly observed treatment in tuberculosis: insights from a mixed-methods cross-sectional study.

Objective: The demanding nature and psychosocial burdens of directly observed treatment (DOT) have opened a path to alternative strategies such as video-observed therapy (VOT), which offers comparable treatment outcomes and patient satisfaction while potentially saving time and reducing costs. The objective of this study was to evaluate the perceptions and experiences of patients and health care professionals regarding DOT and other treatment strategies implemented in Portugal.

Methods: Patients with a confirmed diagnosis of tuberculosis, treated at the Vila Nova de Gaia Outpatient Tuberculosis Centre in the last two years, were asked to complete a brief questionnaire, as were health care professionals working in the northern region of Portugal.

Temporal lobe epilepsy with isolated amygdala enlargement: anatomo-electro-clinical features and long-term outcome.

Background: Temporal lobe epilepsy with isolated amygdala enlargement (TLE-AE) still lacks a definite characterization and controversies exist.

Methods: We conducted a retrospective study identifying brain MRI scans with isolated AE between 2015 and 2021. We collected clinical and paraclinical data of patients with TLE-AE and evaluated the outcome.

Understanding how cardiorespiratory training is implemented to address cardiorespiratory fitness in adults following a stroke: a systematic review.

Purpose: To systematically review the evidence investigating the implementation of cardiorespiratory (CR) training in adults following a stroke and to understand how interventions are prescribed to address cardiorespiratory fitness (CRF).

Methods: Medline, CINAHL, EMBASE, EMCARE, Scopus, PEDro and ProQuest were searched from inception until January 2024. Inclusion criteria were studies that included adults following a stroke, investigated CR training interventions and used standardised CRF assessments.