A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection.

In the context of continuous emergence of SARS-CoV-2 variants of concern (VOCs), one strategy to prevent the severe outcomes of COVID-19 is developing safe and effective broad-spectrum vaccines. Here, we present preclinical studies of a RBD vaccine derived from the Gamma SARS-CoV-2 variant adjuvanted with Alum. The Gamma-adapted RBD vaccine is more immunogenic than the Ancestral RBD vaccine in terms of inducing broader neutralizing antibodies.

Exploring facilitation in virtual simulation in nursing education: A scoping review.

Objective: To systematically map existing research regarding the reflective feedback in virtual simulation in undergraduate nursing education.

Methods: A scoping review was conducted based on the Arksey and O'Malley framework and the PRISMA-ScR.

Results: We included 41 studies from 15 different countries.

Safety and immunogenicity of a SARS-CoV-2 Gamma variant RBD-based protein adjuvanted vaccine used as booster in healthy adults.

A Gamma Variant RBD-based aluminum hydroxide adjuvanted vaccine called ARVAC CG was selected for a first in human clinical trial. Healthy male and female participants (18-55 years old) with a complete COVID-19-primary vaccine scheme were assigned to receive two intramuscular doses of either a low-dose or a high-dose of ARVAC CG. The primary endpoint was safety.

Nursing students' experiences of virtual simulation when using a video conferencing system - a mixed methods study.

Objectives: There is limited knowledge about students' experiences with virtual simulation when using a video conferencing system. Therefore, the aim of this study was to explore how second-year undergraduate nursing students experienced learning through virtual simulations during the COVID-19 pandemic.

Methods: The study had an exploratory design with both quantitative and qualitative approaches.

Patient classification systems used to classify nursing intensity and assess nursing staffing resources in home health care: A scoping review.

Objectives: To identify the patient classification systems used to classify nursing intensity in the assessment of nursing staffing resources currently used in home health care, with a special emphasis on validity, reliability and staff allocation.

Design: Scoping review of internationally published and grey literature, based on a methodological framework by Arksey and O'Malley.

Data Sources: Searches of the electronic databases Cinahl, Medline, Embase and SweMed, the websites Google and Google Scholar and hand searches of reference lists occurred.