Publications by authors named "J Fleck"
Article Synopsis
- Hepacivirus is an RNA virus genus, with hepatitis C virus (HCV) being the most well-known member, and various hepaciviruses have been found in different rodent species.
- A new potential genotype of an unclassified rodent hepacivirus was discovered in a wild cavy, indicating that this virus can cross species boundaries, as it was previously identified in a different rodent species.
- The study's findings, which include complete genome sequencing, could help researchers understand the evolutionary origins of HCV and identify potential virus reservoirs related to human pathogens.
Human neural organoids, generated from pluripotent stem cells in vitro, are useful tools to study human brain development, evolution and disease. However, it is unclear which parts of the human brain are covered by existing protocols, and it has been difficult to quantitatively assess organoid variation and fidelity. Here we integrate 36 single-cell transcriptomic datasets spanning 26 protocols into one integrated human neural organoid cell atlas totalling more than 1.
View Article and Find Full Text PDFChikungunya and Mayaro fevers are viral infectious diseases characterized by fever and arthralgia, for which there are currently no effective vaccines or treatments. The urgent need for novel antiviral agents against Chikungunya virus (CHIKV) and Mayaro virus (MAYV) has led to interest in plant-based compounds that can disrupt the viral replication cycle. (L.
View Article and Find Full Text PDFArticle Synopsis
- - Diazepam (DZP) is a sedative used for anxiety and sleep, but it can have negative side effects; researchers aimed to develop nanocapsules to improve its effectiveness and reduce these side effects.
- - The study involved creating and testing DZP nanocapsules using the nanoprecipitation method, ensuring they were stable and effective through various evaluations, including toxicity tests on C. elegans and mice.
- - Results showed that the nanocapsules safely carried DZP, had high drug entrapment efficiency, and produced a hypnotic effect at lower doses without toxicity, making them a promising alternative to traditional DZP.